Hepatocellular carcinoma: old friends and new tricks
E Kim, P Viatour - Experimental & molecular medicine, 2020 - nature.com
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and a leading
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …
Clonal expansion in non-cancer tissues
N Kakiuchi, S Ogawa - Nature Reviews Cancer, 2021 - nature.com
Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
A targetable LIFR− NF-κB− LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …
YAP/TAZ functions and their regulation at a glance
A Pocaterra, P Romani, S Dupont - Journal of cell science, 2020 - journals.biologists.com
ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …
[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
Chromatin remodellers as therapeutic targets
HA Malone, CWM Roberts - Nature Reviews Drug Discovery, 2024 - nature.com
Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Mutations in ARID1A rank among the most common molecular aberrations in human cancer.
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …
ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer
Mutations in ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, are the most
common alterations of the SWI/SNF complex in estrogen-receptor-positive (ER+) breast …
common alterations of the SWI/SNF complex in estrogen-receptor-positive (ER+) breast …
Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian
SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung …
SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung …
ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis
ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …