In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

There is a progressive deterioration in β-cell function and mass in type 2 diabetics. It was
found that islet function was about 50% of normal at the time of diagnosis, and a reduction in …

It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …

Many agents developed for neuroprotective treatment of Parkinson disease (PD) have
shown great promise in the laboratory, but none have translated to positive results in …

Animal models have enormously contributed to the study of diabetes mellitus, a metabolic
disease with abnormal glucose homeostasis, due to some defect in the secretion or the …

Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in patients with
type 2 diabetes mellitus (T2DM). There is growing evidence from in vivo and in vitro studies …

The molecular pathways leading to islet fibrosis in diabetes are unknown. Therefore, we
studied gene expression in islets of 4-month-old Goto-Kakizaki (GK) and Wistar control rats …

Pioglitazone is an antihyperglycaemic agent that, in the presence of insulin resistance,
increases hepatic and peripheral insulin sensitivity, thereby inhibiting hepatic …

Cholesterol is a critical component of cell membranes, and cellular cholesterol levels and
distribution are tightly regulated in mammals. Recent evidence has revealed a critical role …

The obesity epidemic continues to worsen worldwide, driving metabolic and chronic
inflammatory diseases. Thiazolidinediones, such as rosiglitazone (Rosi), are PPARγ …