The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches

M Lévesque, G Biagini, M de Curtis… - Neuroscience & …, 2021 - Elsevier
Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity …

MY George, MO El-Derany, Y Ahmed… - Expert opinion on …, 2023 - Taylor & Francis
Objectives The present study aims to formulate and evaluate the efficacy of chrysin-loaded
nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as …

Serum untargeted metabolomics analysis of the mechanisms of evodiamine on type 2 diabetes mellitus model rats

Y Yu, Q Lu, F Chen, S Wang, C Niu, J Liao, H Wang… - Food & Function, 2022 - pubs.rsc.org
Evodiamine (EVO) is an alkaloid extracted from Evodia rutaecarpa and has various
pharmacological activities, including hypolipidemic, anti-inflammatory, anti-infective, and …

Synaptic reshaping and neuronal outcomes in the temporal lobe epilepsy

E Ren, G Curia - International Journal of Molecular Sciences, 2021 - mdpi.com
Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy,
characterized by recurrent spontaneous seizures originating in the temporal lobe (s), with …

Potential neuroprotective and autophagy-enhancing effects of alogliptin on lithium/pilocarpine-induced seizures in rats: targeting the AMPK/SIRT1/Nrf2 axis

SS El-Sayed, SO Ali, WW Ibrahim - Life Sciences, 2024 - Elsevier
Background Status epilepticus (SE) as a severe neurodegenerative disease, greatly
negatively affects people's health, and there is an urgent need for innovative treatments. The …

The P2X7 Receptor as a mechanistic biomarker for epilepsy

T Engel - International Journal of Molecular Sciences, 2023 - mdpi.com
Epilepsy, characterized by recurrent spontaneous seizures, is a heterogeneous group of
brain diseases affecting over 70 million people worldwide. Major challenges in the …

Neuroprotective effects of glucagon-like peptide-1 (GLP-1) analogues in epilepsy and associated comorbidities

MA Manavi - Neuropeptides, 2022 - Elsevier
Epilepsy is a common neurological condition induced by losing equilibrium of different
pathway as well as neurotransmitters that affects over 50 million people globally …

Zingerone targets status epilepticus by blocking hippocampal neurodegeneration via regulation of redox imbalance, inflammation and apoptosis

S Rashid, AF Wali, SM Rashid, RM Alsaffar, A Ahmad… - Pharmaceuticals, 2021 - mdpi.com
Epilepsy is an intricate neurological disease where the neurons are severely affected,
leading to the mortality of millions worldwide. Status epilepticus (SE), induced by lithium …

Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and …

M Masoumi, MA Manavi… - Cannabis and …, 2024 - liebertpub.com
Background: Status epilepticus (SE) is a series of seizures that can lead to serious
neurological damages. Cannabidiol (CBD) is extracted from the cannabis plant, which has …

Ginsenoside Rg1 improved learning and memory ability and reduces neuronal apoptosis in epileptic rats through ERK/CREB/BDNF signal pathway

J Zhang, C Zhu, Y Jin, W Shen, Y Pan… - … and Biophysical Research …, 2023 - Elsevier
Objective This research was devoted to estimating the outcomes of ginsenoside Rg1 on
learning and memory ability and neuronal apoptosis in epileptic rats through …