miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart

BC Bernardo, JYY Ooi, RCY Lin… - Future medicinal …, 2015 - Taylor & Francis
miRNAs are small non-coding RNAs (ncRNAs), which regulate gene expression. Here, the
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …

Pseudogenes: pseudo-functional or key regulators in health and disease?

RC Pink, K Wicks, DP Caley, EK Punch, L Jacobs… - Rna, 2011 - rnajournal.cshlp.org
Pseudogenes have long been labeled as “junk” DNA, failed copies of genes that arise
during the evolution of genomes. However, recent results are challenging this moniker; …

miR2Disease: a manually curated database for microRNA deregulation in human disease

Q Jiang, Y Wang, Y Hao, L Juan, M Teng… - Nucleic acids …, 2009 - academic.oup.com
Abstract 'miR2Disease', a manually curated database, aims at providing a comprehensive
resource of microRNA deregulation in various human diseases. The current version of …

MicroRNA-21 in cardiovascular disease

Y Cheng, C Zhang - Journal of cardiovascular translational research, 2010 - Springer
Abstract MicroRNA-21 (miR-21) is a highly expressed microRNA (miRNA) in cardiovascular
system. Recent studies have revealed that its expression is deregulated in heart and …

A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia

X Liu, Y Cheng, S Zhang, Y Lin, J Yang… - Circulation …, 2009 - Am Heart Assoc
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that
negatively regulate gene expression. Functionally, an individual miRNA is as important as a …

A translational study of circulating cell-free microRNA-1 in acute myocardial infarction

Y Cheng, N Tan, J Yang, X Liu, X Cao, P He… - Clinical …, 2010 - portlandpress.com
miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In
contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively …

miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1

CL Lino Cardenas, IS Henaoui, E Courcot… - PLoS …, 2013 - journals.plos.org
As miRNAs are associated with normal cellular processes, deregulation of miRNAs is
thought to play a causative role in many complex diseases. Nevertheless, the precise …

Placental microRNA expression in pregnancies complicated by preeclampsia

DA Enquobahrie, DF Abetew, TK Sorensen… - American journal of …, 2011 - Elsevier
OBJECTIVE:: The role of posttranscription regulation in preeclampsia is largely unknown.
We investigated preeclampsia-related placental microRNA (miRNA) expression using …

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

L Maegdefessel, J Azuma, R Toh… - The Journal of …, 2012 - Am Soc Clin Investig
MicroRNAs (miRs) regulate gene expression at the posttranscriptional level and play crucial
roles in vascular integrity. As such, they may have a role in modifying abdominal aortic …

Semen miRNAs contained in exosomes as non-invasive biomarkers for prostate cancer diagnosis

M Barceló, M Castells, L Bassas, F Vigués, S Larriba - Scientific reports, 2019 - nature.com
Although it is specific for prostatic tissue, serum prostate-specific antigen (PSA) screening
has resulted in an over-diagnosis of prostate cancer (PCa) and many unnecessary biopsies …