CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including
the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple …

CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and
regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with …

Novel effective treatment is direly needed for patients with pancreatic ductal
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …

Stem-like glioma cells reside within a perivascular niche and display hallmark radiation
resistance. An understanding of the mechanisms underlying these properties will be vital for …

Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue
and primarily occur in the brain. Low‐grade tumors of World Health Organization (WHO) …

Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …

The decline of endothelial autophagy is closely related to vascular senescence and disease,
although the molecular mechanisms connecting these outcomes in vascular endothelial …

Abstract The PD-L1 (CD274) immune-checkpoint ligand is often upregulated in cancers to
inhibit T cells and elicit immunosuppression. Independent of this activity, PD-L1 has recently …

The prominent role of CD44 in tumor cell signaling together with its establishment as a
cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC …

Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for
proper regeneration. Altering balanced niche signalling can lead to regenerative disorders …