The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The purpose of this review is to explore self-organizing mechanisms that pattern
microtubules (MTs) and spatially organize animal cell cytoplasm, inspired by recent …

Cells are filled with macromolecules and polymer networks that set scale-dependent viscous
and elastic properties to the cytoplasm. Although the role of these parameters in molecular …

Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it has become clear that cell size is a major …

During early embryogenesis, as cells divide in the developing embryo, the size of
intracellular organelles generally decreases to scale with the decrease in overall cell size …

Chromosome segregation is accomplished by the mitotic spindle, a bipolar micromachine
built primarily from microtubules. Different microtubule populations contribute to spindle …

The function of cellular structures at the mesoscale is dependent on their geometry and
proportionality to cell size. The mitotic spindle is a good example why length and shape of …

Drosophila dividing spermatocytes offer a highly suitable cell system in which to investigate
the coordinated reorganization of microtubule and actin cytoskeleton systems during cell …

Despite drastic cellular changes during cleavage, a mitotic spindle assembles in each
blastomere to accurately segregate duplicated chromosomes. Mechanisms of mitotic spindle …

How cells tune the size of their subcellular parts to scale with cell size is a fundamental
question in cell biology. Until now, most studies on the size control of organelles and other …