The concept of strain in organic compounds is as old as modern organic chemistry and was
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …

Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

For more than one century, photochemical [2+ 2]-cycloadditions have been used by
synthetic chemists to make cyclobutanes, four-membered carbon-based rings. In this …

The development of synthetic strategies for the preparation of bioisosteric compounds is a
demanding undertaking in medicinal chemistry. Numerous strategies have been developed …

Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for
commonly found para-substituted benzene rings in drug design. The utility of these cage …

Synthesis of bicyclic scaffolds has attracted growing interest because they are of high
importance in modern pharmaceutical development. Here we report a strategy to access …

Abstract C (sp 3)-rich bicyclic hydrocarbon scaffolds, as exemplified by bicyclo [1.1. 1]
pentanes, play an increasingly high-profile role as saturated bioisosteres of benzenoids in …

Abstract Design, synthesis and application of benzene bioisosteres have attracted a lot of
attention in the past 20 years. Recently, bicyclo [2.1. 1] hexanes have emerged as highly …

Synthesis of bicyclic scaffolds has attracted tremendous attention because they are playing
an important role as saturated bioisosteres of benzenoids in modern drug discovery. Here …

The ortho-substituted phenyl ring is a basic structural element in chemistry. It is found in
more than three hundred drugs and agrochemicals. During the past decade, scientists have …