Tfos dews ii pathophysiology report
Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …
Retinal microglia: just bystander or target for therapy?
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
Wounding the cornea to learn how it heals
Corneal wound healing studies have a long history and rich literature that describes the data
obtained over the past 70 years using many different species of animals and methods of …
obtained over the past 70 years using many different species of animals and methods of …
Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease
S Sonawane, V Khanolkar, A Namavari… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: We determined whether nucleases are deficient in the tear fluid of dry eye disease
(DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil …
(DED) patients, and whether this causes extracellular DNA (eDNA) and neutrophil …
Immune responses to gene editing by viral and non-viral delivery vectors used in retinal gene therapy
Inherited retinal diseases (IRDs) are a leading cause of blindness in industrialized countries,
and gene therapy is quickly becoming a viable option to treat this group of diseases. Gene …
and gene therapy is quickly becoming a viable option to treat this group of diseases. Gene …
Host defense at the ocular surface
E Pearlman, Y Sun, S Roy, M Karmakar… - International reviews …, 2013 - Taylor & Francis
Microbial infections of the cornea frequently cause painful, blinding and debilitating disease
that is often difficult to treat and may require corneal transplantation. In addition, sterile …
that is often difficult to treat and may require corneal transplantation. In addition, sterile …
Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways
CE Mac Nair, CL Schlamp, AD Montgomery… - Journal of …, 2016 - Springer
Background Retinal ganglion cell (RGC) soma death is a consequence of optic nerve
damage, including in optic neuropathies like glaucoma. The activation of the innate immune …
damage, including in optic neuropathies like glaucoma. The activation of the innate immune …
[HTML][HTML] Changes in murine hyalocytes are valuable early indicators of ocular disease
NN Vagaja, HR Chinnery, N Binz… - … & visual science, 2012 - tvst.arvojournals.org
Purpose.: The distribution, density, and phenotype of hyalocytes or vitreous macrophages in
mouse eyes was examined during normal aging and in models of background diabetic …
mouse eyes was examined during normal aging and in models of background diabetic …
Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease
Optical coherence tomography (OCT) provides non‐invasive, high‐resolution in vivo
imaging of the ocular surface and anterior segment. Over the years, it has become an …
imaging of the ocular surface and anterior segment. Over the years, it has become an …
CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model
A single amino acid mutation near the active site of the CAPN5 protease was linked to the
inherited blinding disorder, autosomal dominant neovascular inflammatory vitreoretinopathy …
inherited blinding disorder, autosomal dominant neovascular inflammatory vitreoretinopathy …