Examining the influence of phosphorylation on peptide ion structure by ion mobility spectrometry-mass spectrometry
Ion mobility spectrometry-mass spectrometry (IMS-MS) techniques are used to study the
general effects of phosphorylation on peptide structure. Cross sections for a library of 66 …
general effects of phosphorylation on peptide structure. Cross sections for a library of 66 …
Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from Sphaerostilbella toxica
Sphaerostilbella toxica is a mycoparasitic fungus that can be found parasitizing wood-decay
basidiomycetes in the southern USA. Organic solvent extracts of fermented strains of S …
basidiomycetes in the southern USA. Organic solvent extracts of fermented strains of S …
Investigation of clozapine and olanzapine reactive metabolite formation and protein binding by liquid chromatography-tandem mass spectrometry
T Geib, M Thulasingam… - Chemical Research in …, 2020 - ACS Publications
Drug-induced toxicity has, in many cases, been linked to oxidative metabolism resulting in
the formation of reactive metabolites and subsequent covalent binding to biomolecules. Two …
the formation of reactive metabolites and subsequent covalent binding to biomolecules. Two …
Substance P in solution: trans-to-cis configurational changes of penultimate prolines initiate non-enzymatic peptide bond cleavages
We report ion mobility spectrometry and mass spectrometry studies of the non-enzymatic
step-by-step degradation of substance P (subP), an 11-residue neuropeptide, with the …
step-by-step degradation of substance P (subP), an 11-residue neuropeptide, with the …
Can mutational analysis be used to assist structure determination of peptides?
L Voronina, V Scutelnic, C Masellis… - Journal of the American …, 2018 - ACS Publications
Mutational analysis is widely used to study the relationship between sequence and structure
of proteins and peptides. It is often assumed that substituting a proline with another amino …
of proteins and peptides. It is often assumed that substituting a proline with another amino …
Substance P in the gas phase: conformational changes and dissociations induced by collisional activation in a drift tube
The work presented below is related to our companion paper in this issue, entitled:
Substance P in solution: trans-to-cis configurational changes of penultimate prolines initiate …
Substance P in solution: trans-to-cis configurational changes of penultimate prolines initiate …
Cis→Trans Isomerization of Pro7 in Oxytocin Regulates Zn2+ Binding
Ion mobility/mass spectrometry techniques are employed to investigate the binding of Zn2+
to the nine-residue peptide hormone oxytocin (OT, Cys1-Tyr2-Ile3-Gln4-Asn5-Cys6-Pro7 …
to the nine-residue peptide hormone oxytocin (OT, Cys1-Tyr2-Ile3-Gln4-Asn5-Cys6-Pro7 …
Penultimate proline in neuropeptides
A recent ion mobility spectrometry-mass spectrometry (IMS-MS) study revealed that tryptic
peptide ions containing a proline residue at the second position from the N-terminus (ie …
peptide ions containing a proline residue at the second position from the N-terminus (ie …
N-Terminal Proline Editing for the Synthesis of Peptides with Mercaptoproline and Selenoproline: Mechanistic Insights Lead to Greater Efficiency in Proline Native …
BA Ludwig, CR Forbes, NJ Zondlo - ACS Chemical Biology, 2024 - ACS Publications
Native chemical ligation (NCL) at proline has been limited by cost and synthetic access. In
addition, prior examples of NCL using mercaptoproline have exhibited stalling of the …
addition, prior examples of NCL using mercaptoproline have exhibited stalling of the …
Multiple gas-phase conformations of proline-containing peptides: is it always cis/trans isomerization?
Ion mobility-mass spectrometry (IM-MS) is often employed to look at the secondary, tertiary,
and quaternary structures of naked peptides and proteins in the gas-phase. Recently, it has …
and quaternary structures of naked peptides and proteins in the gas-phase. Recently, it has …