Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

Spatial transcriptomics (ST) technologies are revolutionizing the way to explore the spatial
architecture of tissues. Currently, ST data analysis is often restricted to a single two …

Congenital heart disease (CHD) is the most common congenital anomaly in newborn
babies. Cardiac malformations have been produced in multiple experimental animal …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Heart development is exquisitely sensitive to the precise temporal regulation of thousands of
genes that govern developmental decisions during differentiation. However, we currently …

Rationale: Cardiomyocytes (CMs) differentiated from human pluripotent stem cells (PSCs)
are increasingly being used for cardiovascular research, including disease modeling, and …

Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …

Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …

Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …