Non-biological artificial liver support (ALS) devices aim to remove albumin-bound and water-
soluble toxins arising as a result of liver failure. They do not directly improve the liver …

Severe liver failure is common and carries a high mortality risk in patients with both acute
and acute-on-chronic liver failure. The failing liver constitutes a medical emergency, and in …

Background Post-hepatectomy liver failure (PHLF) remains a serious complication after
major liver resection with severe 90-day mortality. Molecular adsorbent recirculating system …

Background. If “bridging” to allo-transplantation (Tx) is to be achieved by a pig liver
xenograft, adequate hepatic function needs to be assured. Methods. We have studied …

Abstract Background. Molecular Adsorbents Recirculating System (MARS) is an
extracorporeal liver support system eliminating albumin-bound and water-soluble …

In artificial extracorporeal liver support systems, albumin-bound toxins such as bilirubin, bile
acids, or aromatic amino acids are removed by adsorption to polymer beads. To overcome …

The liver is the only organ which can regenerate and, thus, potentially negate the need for
transplantation in acute liver failure (ALF). Cerebral edema and sepsis are leading causes of …

Enthusiasm in liver support devices is justified as many nonrandomized studies have
suggested some biochemical and clinical benefits. The results of several ongoing …

Acute-on-chronic liver failure (ACLF) is associated with multiorgan dysfunction requiring
intensive care support and carries an exceptionally high risk of mortality. Decompensation of …

Background & Aims Extracorporeal blood purification systems for supportive therapy of liver
failure are widely used. We developed a novel blood purification system, named Li's artificial …