Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

Background Accumulation of extracellular matrix in organs and tissues is a feature of both
aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis …

Fibrillar proteins are principal components of extracellular matrix (ECM) that confer
mechanical properties to tissues. Fibrosis can result from wound repair in nearly every tissue …

Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on
kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of …

Chronic kidney disease (CKD) can progress to kidney failure and require dialysis or
transplantation, while early diagnosis can alter the course of disease and lead to better …

Background There is a significant global demand for precise diagnosis and effective
treatment of IgA nephropathy (IgAN), with innate immunity, particularly the complement …

Most tissue biopsies from patients in hospital environments are formalin-fixed and paraffin-
embedded (FFPE) for long-term storage. This fixation process produces a modification in the …

Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in
axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high …