ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Osteogenesis Imperfecta (OI) comprises a heterogeneous group of patients who share bone
fragility and deformities as the main characteristics, albeit with different degrees of severity …

Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at
specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too …

The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …

Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …

Conserved catabolic pathways operate to remove aberrant polypeptides from the
endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best …

Highly abundant in mammals, collagens define the organization of tissues and participate in
cell signalling. Most of the 28 vertebrate collagens, with the exception of collagens VI, VII …

Cellular response to protein misfolding underlies multiple diseases. Collagens are the most
abundant vertebrate proteins, yet little is known about cellular response to misfolding of their …

The realization that the meticulous organization of cellular organelles is not required for the
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …