A review of currently identified small molecule modulators of microRNA function
EN Van Meter, JA Onyango, KA Teske - European journal of medicinal …, 2020 - Elsevier
Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …
A novel phytochemical, DIM, inhibits proliferation, migration, invasion and TNF-α induced inflammatory cytokine production of synovial fibroblasts from rheumatoid …
H Du, X Zhang, Y Zeng, X Huang, H Chen… - Frontiers in …, 2019 - frontiersin.org
In rheumatoid arthritis (RA) pathogenesis, activated RA fibroblast-like synoviocytes (RA-
FLSs) exhibit similar proliferative features as tumor cells and subsequent erosion to cartilage …
FLSs) exhibit similar proliferative features as tumor cells and subsequent erosion to cartilage …
[HTML][HTML] 3, 3'-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors …
B Biersack - Cancer Drug Resistance, 2020 - ncbi.nlm.nih.gov
Indoles of cruciferous vegetables are promising anti-tumor agents. Studies with indole-3-
carbinol and its dimeric product, 3, 3'-diindolylmethane (DIM), suggest that these …
carbinol and its dimeric product, 3, 3'-diindolylmethane (DIM), suggest that these …
Can Current Molecular Docking Methods Accurately Predict RNA Inhibitors?
KKJ Gunasinghe, IRH Ginjom, HS San… - Journal of Chemical …, 2024 - ACS Publications
Ribonucleic acids (RNAs), particularly the noncoding RNAs, play key roles in cancer,
making them attractive drug targets. While conventional methods such as high throughput …
making them attractive drug targets. While conventional methods such as high throughput …
Investigating ligand-mediated conformational dynamics of pre-miR21: A machine-learning-aided enhanced sampling study
MicroRNAs (miRs) are short, noncoding RNA strands that regulate the activity of mRNAs by
affecting the repression of protein translation, and their dysregulation has been implicated in …
affecting the repression of protein translation, and their dysregulation has been implicated in …
Regulating pri/pre-microRNA up/down expressed in cancer proliferation, angiogenesis and metastasis using selected potent triterpenoids
MicroRNAs (miRNAs) play a crucial role in cancer progression by selectively inducing
translational degradation of messenger RNA (mRNA) via sequence-specific interactions …
translational degradation of messenger RNA (mRNA) via sequence-specific interactions …
Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3, 3′-diindolylmethane and chemotherapy drugs
SV Nikulin, BY Alekseev, NS Sergeeva, PA Karalkin… - Biochimie, 2020 - Elsevier
Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently
it was revealed that small molecules have the potential to act as microRNA silencers …
it was revealed that small molecules have the potential to act as microRNA silencers …
Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
Single nucleotide variations in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
are associated with many neurodegenerative diseases, including Nasu-Hakola disease …
are associated with many neurodegenerative diseases, including Nasu-Hakola disease …
Dietary flavonoid narirutin as a prospective antagonist of oncogenic pri/pre‐microRNAs
S Singh, PN Srivastava, A Meena… - Phytotherapy …, 2022 - Wiley Online Library
MicroRNAs (miRNAs) are involved in cancer progression via translational degradation in a
sequence‐specific manner of the 3′‐untranslated region (3′ UTR) of messenger RNA …
sequence‐specific manner of the 3′‐untranslated region (3′ UTR) of messenger RNA …
Morpho‐functional analyses reveal that changes in the chemical structure of a marine bisindole alkaloid alter the cytotoxic effect of its derivatives
S Burattini, M Battistelli, M Verboni… - Microscopy …, 2022 - Wiley Online Library
bis (6‐bromo‐1 H‐indol‐3‐yl) ethanamine, a marine bisindole alkaloid, showed anticancer
property in several tumor cell lines thanks to the presence of a 3, 3′‐diindolylmethane …
property in several tumor cell lines thanks to the presence of a 3, 3′‐diindolylmethane …