Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

Articular cartilage is commonly described as a tissue that is made of up to 80% water, is
devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the …

Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

Background Osteoarthritis (OA) is the most common joint disease worldwide. In the past
decade, mesenchymal stem cells (MSCs) have been used widely for the treatment of OA. A …

Cartilage injury is extremely common and leads to joint dysfunction. Existing joint prostheses
do not remodel with host joint tissue. However, developing large-scale biomimetic …

The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in
the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone …

Osteoarthritis (OA), a prevalent chronic condition with a striking impact on quality of life,
represents an enormous societal burden that increases greatly as populations age. Yet no …

The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

Cartilage is essential throughout vertebrate life. It starts developing in embryos when
osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous …