DNA mismatch repair in cancer

M Baretti, DT Le - Pharmacology & therapeutics, 2018 - Elsevier
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent
polymorphism in short repetitive DNA sequences and single nucleotide substitution, as …

Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)

SR Cairns, JH Scholefield, RJ Steele, MG Dunlop… - Gut, 2010 - gut.bmj.com
The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …

[图书][B] Applications of prediction models

EW Steyerberg, EW Steyerberg - 2009 - Springer
Applications of prediction models | SpringerLink Skip to main content Advertisement
SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …

Identification of Lynch syndrome among patients with colorectal cancer

L Moreira, F Balaguer, N Lindor, A De la Chapelle… - Jama, 2012 - jamanetwork.com
Context Lynch syndrome is the most common form of hereditary colorectal cancer (CRC)
and is caused by germline mutations in DNA mismatch repair (MMR) genes. Identification of …

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC

HFA Vasen, P Watson, JP Mecklin, HT Lynch - Gastroenterology, 1999 - Elsevier
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome)
proposed by the International Collaborative Group on HNPCC - ScienceDirect Skip to main …

Hereditary cancer predisposition syndromes

JE Garber, K Offit - Journal of clinical oncology, 2005 - ascopubs.org
Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

HFA Vasen, G Möslein, A Alonso, I Bernstein… - Journal of medical …, 2007 - jmg.bmj.com
Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the
development of colorectal cancer, endometrial cancer and various other cancers, and is …

Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review

NM Lindor, GM Petersen, DW Hadley, AY Kinney… - Jama, 2006 - jamanetwork.com
ContextAbout 2% of all colorectal cancer occurs in the context of the autosomal dominantly
inherited Lynch syndrome, which is due to mutations in mismatch repair genes. Potential risk …

Genomic instability and colon cancer

WM Grady - Cancer and metastasis reviews, 2004 - Springer
Colorectal cancer affected∼ 135,000 people in the United States in 2001, resulting in
57,000 deaths. At the cellular level, colorectal cancer results from the progressive …

Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal …

V Piñol, A Castells, M Andreu, S Castellví-Bel… - Jama, 2005 - jamanetwork.com
ContextThe selection of individuals for hereditary nonpolyposis colorectal cancer (HNPCC)
genetic testing is challenging. Recently, the National Cancer Institute outlined a new set of …