Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR)
signaling pathway is important in a variety of biological activities, including cellular …

mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR
regulates cell growth and proliferation in response to a wide range of cues, and its signaling …

Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in
tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical …

The mechanistic/mammalian target of rapamycin (mTOR) plays a master role in cell
proliferation and growth in response to insulin, amino acids, energy levels, and oxygen …

Growth factors and nutrients enhance protein synthesis and suppress overall protein
degradation by activating the protein kinase mammalian target of rapamycin (mTOR) …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …

Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a
common molecular event in a variety of pathological settings, including genetic tumor …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …