Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

The vitreous humor as a barrier to nanoparticle distribution

J Mains, CG Wilson - Journal of ocular pharmacology and …, 2013 - liebertpub.com
The vitreous humor represents a significant barrier to the penetration of nanoparticulate-
based ocular drug delivery systems. The gel structure and biochemical components of the …

[HTML][HTML] Prolonged inhibition of inflammation in osteoarthritis by triamcinolone acetonide released from a polyester amide microsphere platform

I Rudnik-Jansen, S Colen, J Berard, S Plomp… - Journal of Controlled …, 2017 - Elsevier
Controlled biomaterial-based corticosteroid release might circumvent multiple injections and
the accompanying risks, such as hormone imbalance and muscle weakness, in …

Preclinical challenges for developing long acting intravitreal medicines

S Awwad, C Henein, N Ibeanu, PT Khaw… - European Journal of …, 2020 - Elsevier
The majority of blinding conditions arise due to chronic pathologies in the retina. During the
last two decades, antibody-based medicines administered by intravitreal injection directly …

Crystalline retinopathy: unifying pathogenic pathways of disease

JL Kovach, H Isildak, D Sarraf - Survey of ophthalmology, 2019 - Elsevier
Crystalline retinopathies may be associated with different etiologies including genetic, toxic,
degenerative, idiopathic, and iatrogenic causes. We outline the various types of crystalline …

[HTML][HTML] Steroid differentiation: the safety profile of various steroids on retinal cells in vitro and their implications for clinical use (an American Ophthalmological Society …

BD Kuppermann, LC Zacharias… - Transactions of the …, 2014 - ncbi.nlm.nih.gov
Purpose: To determine if potentially viable alternatives to the clinical use of intravitreal
triamcinolone acetonide should be considered based on a comparative assessment of the in …

Safety of intradiscal delivery of triamcinolone acetonide by a poly (esteramide) microsphere platform in a large animal model of intervertebral disc degeneration

I Rudnik-Jansen, A Tellegen, M Beukers, F Öner… - The Spine Journal, 2019 - Elsevier
BACKGROUND CONTEXT Local corticosteroids have been used to relieve symptoms of
chronic low back pain, although treatment effects have been shown to wear off relatively fast …

[HTML][HTML] Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment

H Kawano, T Ito, S Yamada, T Hashiguchi… - Laboratory …, 2014 - Elsevier
Histones are DNA-binding proteins and are involved in chromatin remodeling and
regulation of gene expression. Histones can be released after tissue injuries, and the …

[HTML][HTML] Particle-induced endophthalmitis: possible mechanisms of sterile endophthalmitis after intravitreal triamcinolone

H Otsuka, H Kawano, S Sonoda… - … & visual science, 2013 - arvojournals.org
Methods.: The clinical records of 21 eyes that had sterile endophthalmitis after IVTA were
reviewed. Cytologic studies were performed, and cytokine and chemokine profiles in the …

Safety Profile of Lutein-Versus Triamcinolone Acetonide–Based Vitreous Staining

F Lazzara, F Conti, M Ferrara, M Lippera… - … Vision Science & …, 2023 - tvst.arvojournals.org
Purpose: To assess the safety profile of a new lutein-based vitreous dye (LB-VD) formulation
compared with various triamcinolone acetonide (TA) formulations with and without …