The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in
cellular processes, such as vesicular transport, cell motility and mitosis. Expression of …

Communication in bilaterian nervous systems is mediated by electrical and secreted signals;
however, the evolutionary origin and relation of neurons to other secretory cell types has not …

The pace of human brain development is highly protracted compared with most other
species,,,,,–. The maturation of cortical neurons is particularly slow, taking months to years to …

Abstract Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and
other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the …

The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

Pro-neural transcription factors and small molecules can induce the reprogramming of
fibroblasts into functional neurons; however, the immediate-early molecular events that …

Apical organs are relatively simple larval nervous systems. The extent to which apical
organs are evolutionarily related to the more complex nervous systems of other animals …

The expansion of brain size is accompanied by a relative enlargement of the subventricular
zone during development. Epithelial-like neural stem cells divide in the ventricular zone at …

This review accompanies a 2016 SFN mini-symposium presenting examples of current
studies that address a central question: How do neural stem cells (NSCs) divide in different …