The roles of cancer stem cells and therapy resistance in colorectal carcinoma

PK Das, F Islam, AK Lam - Cells, 2020 - mdpi.com
Cancer stem cells (CSCs) are the main culprits involved in therapy resistance and disease
recurrence in colorectal carcinoma (CRC). Results using cell culture, animal models and …

Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance

N Ebrahimi, M Afshinpour, SS Fakhr… - Critical Reviews in …, 2023 - Elsevier
Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some
cases, treatment can increase patient survival and reduce cancer recurrence, in many …

Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

VR Silva, LS Santos, RB Dias… - Cancer …, 2021 - Wiley Online Library
Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer

KW Hon, NS Ab-Mutalib, NMA Abdullah, R Jamal… - Scientific reports, 2019 - nature.com
Chemo-resistance is associated with poor prognosis in colorectal cancer (CRC), with the
absence of early biomarker. Exosomes are microvesicles released by body cells for …

Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future

AM Hirst, FM Frame, M Arya, NJ Maitland, D O'Connell - Tumor Biology, 2016 - Springer
The field of plasma medicine has seen substantial advances over the last decade, with
applications developed for bacterial sterilisation, wound healing and cancer treatment. Low …

Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer

B Kulkarni, P Kirave, P Gondaliya, K Jash, A Jain… - Drug Discovery …, 2019 - Elsevier
Highlights•Exosomal miRNA plays a vital part in the initiation of dysregulated molecular
events.•Understanding exosomal miRNA in chemoresistance, immune-escape and …

[HTML][HTML] Cancer stem cells: cellular plasticity, niche, and its clinical relevance

G Lee, RR Hall III, AU Ahmed - Journal of stem cell research & …, 2016 - ncbi.nlm.nih.gov
Cancer handles an estimated 7.6 million deaths worldwide per annum. A recent theory
focuses on the role Cancer Stem Cells (CSCs) in driving tumorigenesis and disease …

Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

K Qureshi-Baig, P Ullmann, S Haan, E Letellier - Molecular cancer, 2017 - Springer
Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem
cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure …

Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells

F El Khoury, L Corcos, S Durand… - International …, 2016 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most aggressive cancers worldwide. Several
anticancer agents are available to treat CRC, but eventually cancer relapse occurs. One …

Nobiletin and xanthohumol sensitize colorectal cancer stem cells to standard chemotherapy

A Turdo, A Glaviano, G Pepe, F Calapà, S Raimondo… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer stem cells (CR-CSCs) play a pivotal role in the therapy
resistance and relapse of CRC patients. Herein we demonstrate that new treatment …