[HTML][HTML] Immunosuppression in lung transplantation

JL Scheffert, K Raza - Journal of thoracic disease, 2014 - ncbi.nlm.nih.gov
Lung transplantation can be a life-saving procedure for those with end-stage lung diseases.
Unfortunately, long term graft and patient survival are limited by both acute and chronic …

Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation

AL Silva, C Peres, J Conniot, AI Matos, L Moura… - Seminars in …, 2017 - Elsevier
Nanotechnology-based strategies can dramatically impact the treatment, prevention and
diagnosis of a wide range of diseases. Despite the unprecedented success achieved with …

Tacrolimus prevents mechanical and humoral alterations in brain death–induced lung injury in pigs

A Belhaj, L Dewachter, E Hupkens… - American journal of …, 2022 - atsjournals.org
Rationale: Donor brain death–induced lung injury may compromise graft function after
transplantation. Establishing strategies to attenuate lung damage remains a challenge …

Nanotechnological approaches to immunosuppression and tolerance induction

K Patel, C Atkinson, D Tran, SN Nadig - Current transplantation reports, 2017 - Springer
Abstract Purpose of Review Several pre-clinical studies have engineered nanoparticles for
immune regulation and have shown promising results in the fields of autoimmunity and …

The significance and mechanism of propofol on treatment of ischemia reperfusion induced lung injury in rats

P Yang, N Yang, X Zhang, X Xu - Cell biochemistry and biophysics, 2014 - Springer
This study is aimed to investigate the efficacy and underlying the mechanism of propofol in
treatment of ischemia reperfusion (IR)-induced lung injury in rats, providing a novel insight of …

[HTML][HTML] The efficacy of inhaled nanoparticle tacrolimus in preventing rejection in an orthotopic rat lung transplant model

NA Das, JI Peters, JD Simmons, Y Wang… - The Journal of Thoracic …, 2017 - Elsevier
Objective The immunosuppressive efficacy of inhaled nanoparticle tacrolimus was
compared with systemic tacrolimus in a rodent allogeneic lung transplant model. Methods …

Calcineurin Inhibitors in Lung Donors to Attenuate Ischemia–Reperfusion Injury in Recipients: Next Steps?

D Rozenberg, MO Meade - … Journal of Respiratory and Critical Care …, 2022 - atsjournals.org
11. Alba GA, Samokhin AO, Wang RS, et al. Pulmonary endothelial NEDD9 and the
prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 …

Pharmaceutical care in transplantation: current challenges and future opportunities

JR Covvey, EE Mancl - Nanomedicine, 2019 - Taylor & Francis
The United Network for Organ Sharing, the nonprofit organization that contracts with the
government to manage the country's organ transplantation system, reports that over 750,000 …

Calcineurin inhibition in deceased organ donors: A systematic review and meta-analysis of Preclinical studies

F D'Aragon, W Rousseau, R Breau… - Transplantation …, 2023 - journals.lww.com
Background. Preconditioning deceased organ donors with calcineurin inhibitors (CNIs) may
reduce ischemia–reperfusion injury to improve transplant outcomes. Methods. We searched …

Differential effects of the immunosuppressive calcineurin inhibitors cyclosporine-A and tacrolimus on ovulation in a murine model

F Zakerkish, MJ Soriano… - Human …, 2021 - academic.oup.com
STUDY QUESTION Do therapeutic levels of cyclosporine-A and tacrolimus affect ovulation
in a rat gonadotrophin-induced ovulation model? SUMMARY ANSWER Cyclosporine-A, but …