Infectious diseases continue to threaten human and animal health and welfare globally,
impacting millions of lives and causing substantial economic loss. The use of antibacterials …

BACKGROUND:: Tigecycline, the first glycylcycline to be approved by the US Food and
Drug Administration, is a structural analogue of minocycline that was designed to avoid …

Objectives: The purpose of this study was to determine the tissue and corresponding serum
concentration of tigecycline at selected time points in gall bladder, bile, colon, bone, synovial …

Neutrophils are important assets in defense against invading bacteria like staphylococci.
However,(dysfunctioning) neutrophils can also serve as reservoir for pathogens that are …

La creciente tasa de resistencia de Staphylococcus aureus a meticilina (SARM) observada
en la década de los años 90, generó importantes lineas de estudio de nuevos antibióticos …

The rapid antibiotic resistance development has created a major demand for new
antimicrobial agents that can combat resistant strains such as methicillin-resistant S. aureus …

Introduction: As the spread of multidrug-resistant (MDR) and extensive drug-resistant (XDR)
organisms constitutes a real threat for patients, new antimicrobials are needed. Tigecycline …

This review summarises the changing epidemiology of resistance to cephalosporins and
fluoroquinolones among the Enterobacteriaceae since the 1980s and its potential impact on …

Bacterial heteroresistance has been identified in several combinations of bacteria and
antibiotics, and it complicated the therapeutic strategies. Tigecycline is being used as one of …

This brief review summarizes recently published data on the pharmacokinetics and
pharmacodynamics of tigecycline in man. Significant pharmacokinetic data are now …