Adipose-tissue plasticity in health and disease

A Sakers, MK De Siqueira, P Seale, CJ Villanueva - Cell, 2022 - cell.com
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Adipose tissue at single-cell resolution

B Maniyadath, Q Zhang, RK Gupta, S Mandrup - Cell metabolism, 2023 - cell.com
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Adipogenesis and metabolic health

AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

CR Kahn, G Wang, KY Lee - The Journal of clinical …, 2019 - Am Soc Clin Investig
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

[HTML][HTML] Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution

AK Sárvári, EL Van Hauwaert, LK Markussen… - Cell metabolism, 2021 - cell.com
Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

L Vishvanath, RK Gupta - The Journal of clinical …, 2019 - Am Soc Clin Investig
The manner in which white adipose tissue (WAT) expands and remodels directly impacts the
risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT …

Mesenchymal stem cell perspective: cell biology to clinical progress

MF Pittenger, DE Discher, BM Péault… - NPJ Regenerative …, 2019 - nature.com
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …

Adipose tissue fibrosis in obesity: etiology and challenges

G Marcelin, EL Gautier, K Clément - Annual review of physiology, 2022 - annualreviews.org
Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

The evolving view of thermogenic adipocytes—ontogeny, niche and function

F Shamsi, CH Wang, YH Tseng - Nature Reviews Endocrinology, 2021 - nature.com
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …