Transforming growth factor‐β, matrix metalloproteinases, and urokinase‐type plasminogen activator interaction in the cancer epithelial to mesenchymal transition
Transforming growth factor‐β (TGF‐β) is a pleiotropic factor that acts as a tumor suppressor
in the early stages, while it exerts tumor promoting activities in advanced stages of cancer …
in the early stages, while it exerts tumor promoting activities in advanced stages of cancer …
Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells
A Pantovic, A Krstic, K Janjetovic, J Kocic… - Bone, 2013 - Elsevier
We investigated the role of AMP-activated protein kinase (AMPK), Akt, mammalian target of
rapamycin (mTOR), autophagy and their interplay in osteogenic differentiation of human …
rapamycin (mTOR), autophagy and their interplay in osteogenic differentiation of human …
Transforming growth factor‐beta and urokinase‐type plasminogen activator: Dangerous partners in tumorigenesis—Implications in skin cancer
JF Santibanez - International Scholarly Research Notices, 2013 - Wiley Online Library
Transforming growth factor‐beta (TGF‐β) is a pleiotropic factor, with several different roles in
health and disease. TGF‐β has been postulated as a dual factor in tumor progression, since …
health and disease. TGF‐β has been postulated as a dual factor in tumor progression, since …
Integrative analysis of blood transcriptome profiles in small-cell lung cancer patients for identification of novel chemotherapy resistance-related biomarkers
F Yang, J Fan, R Yang, Y Cun - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Chemoresistance constitutes a prevalent factor that significantly impacts
thesurvival of patients undergoing treatment for smal-cell lung cancer (SCLC) …
thesurvival of patients undergoing treatment for smal-cell lung cancer (SCLC) …
The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar
FM Conedera, AMQ Pousa, N Mercader… - Molecular …, 2021 - Springer
Background Contrasting with zebrafish, retinal regeneration from Müller cells (MCs) is
largely limited in mammals, where they undergo reactive gliosis that consist of a …
largely limited in mammals, where they undergo reactive gliosis that consist of a …
Genome-wide association study of prognosis in advanced non–small cell lung cancer patients receiving platinum-based chemotherapy
L Hu, C Wu, X Zhao, R Heist, L Su, Y Zhao, B Han… - Clinical Cancer …, 2012 - AACR
Purpose: Genetic variation may influence chemotherapy response and overall survival in
cancer patients. Experimental design: We conducted a genome-wide scan in 535 advanced …
cancer patients. Experimental design: We conducted a genome-wide scan in 535 advanced …
[HTML][HTML] SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes
J Kocic, D Bugarski, JF Santibanez - European journal of cancer, 2012 - Elsevier
Transforming growth factor-β1 (TGF-β1) stimulates the extracellular matrix degrading
proteases expression and cell migration in order to enhance cancer cells malignancy. In the …
proteases expression and cell migration in order to enhance cancer cells malignancy. In the …
Urokinase type plasminogen activator and the molecular mechanisms of its regulation in cancer
JF Santibanez - Protein and peptide letters, 2017 - ingentaconnect.com
Background: Urokinase type plasminogen activator (uPA) is a 53-kDa serine protease
initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is …
initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is …
IL-17 and FGF signaling involved in mouse mesenchymal stem cell proliferation
The mouse is a suitable experimental model to study the biology of mesenchymal stem cells
(MSCs), as well as to be used in biocompatibility studies and tissue engineering models …
(MSCs), as well as to be used in biocompatibility studies and tissue engineering models …
Interleukin-17 modulates myoblast cell migration by inhibiting urokinase type plasminogen activator expression through p38 mitogen-activated protein kinase
J Kocić, JF Santibañez, A Krstić, S Mojsilović… - … International Journal of …, 2013 - Elsevier
Interleukin-17 belongs to a family of pro-inflammatory cytokines with pleiotropic effects,
which can be associated with several inflammatory diseases of the muscle tissue. Although …
which can be associated with several inflammatory diseases of the muscle tissue. Although …