What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?
Henoch-Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) are considered to …

Immunoglobulin A (IgA) is the most abundant isotype of antibodies, provides a first line of
defense at mucosal surfaces against pathogens, and thereby contributes to mucosal …

Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain
unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where …

Since immunoglobulin A nephropathy (IgAN) was first described in the seminal papers by
Berger [1, 2], we have learned much descriptively about its epidemiology, associations …

The biological functions of immunoglobulin (Ig) A antibodies depend primarily on their
interaction with cell surface receptors. Four IgA receptors are presently characterized. The …

Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three
patients. Background In IgA nephropathy (IgAN), circulating IgA1 molecules display an …

The pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN), the most prevalent form of
glomerulonephritis worldwide, involves circulating macromolecular IgA1 complexes …

IgA nephropathy (IgAN) is a common cause of renal failure worldwide. Treatment is limited
because of a complex pathogenesis, including unknown factors favoring IgA1 deposition in …

The mechanism of IgA deposition in the kidneys in IgA nephropathy is unknown, Mesangial
IgA is of the IgA I subclass, and since no consistent antigenic target for the IgA I has been …

IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune
disease. Galactose-deficient IgA1 is recognized by unique autoantibodies, resulting in the …