Mapping genetic interactions in cancer: a road to rational combination therapies
B Tutuncuoglu, NJ Krogan - Genome Medicine, 2019 - Springer
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP)
inhibitors and BRCA genes, which are involved in homologous recombination, led to the …
inhibitors and BRCA genes, which are involved in homologous recombination, led to the …
[HTML][HTML] The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling
Abstract The Hedgehog/GLI (HH/GLI) signaling pathway plays a critical role in human
oncogenesis. Unfortunately, the clinical use of HH inhibitor (s) has been associated with …
oncogenesis. Unfortunately, the clinical use of HH inhibitor (s) has been associated with …