Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage

JM Gutiérrez, A Rucavado, T Escalante, C Díaz - Toxicon, 2005 - Elsevier
Zinc-dependent metalloproteinases are responsible for the hemorrhagic activity
characteristic of viperid snake venoms. Snake venom metalloproteinases (SVMPs) are …

Metalloproteases affecting blood coagulation, fibrinolysis and platelet aggregation from snake venoms: Definition and nomenclature of interaction sites

RM Kini, CY Koh - Toxins, 2016 - mdpi.com
Snake venom metalloproteases, in addition to their contribution to the digestion of the prey,
affect various physiological functions by cleaving specific proteins. They exhibit their …

Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders

S Larréché, JP Chippaux, L Chevillard… - International Journal of …, 2021 - mdpi.com
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of
clinical and biological syndromes including local and systemic bleeding, incoagulability …

Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases

AS Kamiguti, CRM Hay, RDG Theakston, M Zuzel - Toxicon, 1996 - Elsevier
Local and systemic haemorrhage are common consequences of crotaline and viperine
envenoming. Several studies carried out using purified toxins have indicated that local …

The venom composition of the snake tribe Philodryadini:'Omic'techniques reveal intergeneric variability among South American racers

EC Tioyama, JD Bayona-Serrano, JA Portes-Junior… - Toxins, 2023 - mdpi.com
Snakes of the Philodryadini tribe are included in the Dipsadidae family, which is a diverse
group of rear-fanged snakes widespread in different ecological conditions, including …

Timeline of key events in snake venom metalloproteinase research

JW Fox, SMT Serrano - Journal of proteomics, 2009 - Elsevier
It is reasonable to state that snake venom toxinology has been actively pursued for at least
the past 400 to 500 years. Early on it was appreciated that the venoms of the Viperidae …

[HTML][HTML] Comparative analysis of newborn and adult Bothrops jararaca snake venoms

TC Antunes, KM Yamashita, KC Barbaro, M Saiki… - Toxicon, 2010 - Elsevier
Different clinical manifestations have been reported to occur in patients bitten by newborn
and adult Bothrops jararaca snakes. Herein, we studied the chemical composition and …

Importance of snake venom metalloproteinases in cell biology: effects on platelets, inflammatory and endothelial cells

AM Moura-da-Silva, D Butera… - Current pharmaceutical …, 2007 - ingentaconnect.com
Snake venom metalloproteinases (SVMPs) are widely distributed in snake venoms and play
important roles in hemostatic disorders and local tissue damage that follows snakebite. The …

Inhibition of collagen-induced platelet aggregation as the result of cleavage of α2β1-integrin by the snake venom metalloproteinase jararhagin

AS KAMIGUTI, CRM HAY, M Zuzel - Biochemical Journal, 1996 - portlandpress.com
Jararhagin is a high-molecular-mass (52 kDa) haemorrhagic metalloproteinase from
Bothrops jararaca venom and a member of the metalloproteinase/disintegrin/cysteine-rich …

Functional variability of snake venom metalloproteinases: adaptive advantages in targeting different prey and implications for human envenomation

JL Bernardoni, LF Sousa, LS Wermelinger, AS Lopes… - PLoS …, 2014 - journals.plos.org
Snake venom metalloproteinases (SVMPs) are major components in most viperid venoms
that induce disturbances in the hemostatic system and tissues of animals envenomated by …