Background It has been postulated that anesthetic agents that reduce cerebral metabolic
rate will protect the brain against ischemia when electroencephalographic (EEG) activity is …

Two groups of rats were tested on a variety of motor and cognitive tasks after either 10
minutes of two-vessel occlusion forebrain ischemia (n= 8) or sham operative procedures (n …

IMPLICATIONS: The dose-dependent effects of isoflurane were examined in a rat model of
severe forebrain ischemia. Outcome across a range of variables was better in rats …

Background Postischemic endogenous neurogenesis can be dose-dependently modulated
by volatile anesthetics. The intravenous anesthetic propofol is used during operations with a …

Strain differences in the vulnerability of hippocampal neurons to an ischaemic insult were
investigated in Sprague-Dawley, Wistar and Fischer 344 rats. Transient global brain …

Background Isoflurane-anesthetized rats have better outcome from global cerebral ischemia
than rats anesthetized with fentanyl and nitrous oxide. The authors wanted to determine …

Abstract Halothane anesthetized Sprague-Dawley rats underwent 10 min of bilateral carotid
artery occlusion with mean arterial pressure (MAP) held at 30, 50 or 60 mmHg. Sham rats …

Background Isoflurane improves outcome from near-complete forebrain ischemia in rats
compared with fentanyl-nitrous oxide (N2O). Sympathetic ganglionic blockade with …

We previously showed that preischemic administration of high-dose isoflurane worsened the
outcome from severe forebrain ischemia in rats. Conversely, high doses of sevoflurane have …

Abstract Purpose Prostaglandin E 1 (PGE 1) has been shown to provide short-term
neuroprotection against various types of brain ischemia in a dose-dependent manner in …