Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …

The extracellular matrix (ECM) plays an important role in cancer progression. It can be
divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior …

The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …