Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Each year, approximately 795,000 people experience a new or recurrent stroke. Of all
strokes, 84% are ischemic, 13% are intracerebral hemorrhage (ICH) strokes, and 3% are …

Valproate, an anticonvulsant drug used to treat bipolar disorder, was studied for its ability to
promote neurogenesis from embryonic rat cortical or striatal primordial stem cells. Six days …

Aberrant upregulation of COX-2 enzyme resulting in accumulation of PGE2 in a cancer cell
environment is a marker for progression of many cancers, including breast cancer. Four …

Alzheimer's disease (AD) is associated with gliosis, neuroinflammation and higher levels of
prostaglandins. Conflicting roles for cyclooxygenases and prostaglandins in the …

Electrical excitability—the ability to fire and propagate action potentials—is a signature
feature of neurons. How neurons become excitable during development and whether …

Abstract Prostaglandin E2 (PGE 2) is a natural lipid-derived molecule that is involved in
important physiological functions. Abnormal PGE 2 signalling has been associated with …

Abstract Cyclin‐dependent kinase 5 (Cdk5), a neuronal Cdc2‐like kinase, exhibits a variety
of functions in neuronal differentiation and neurocytoskeleton dynamics, as well as neuronal …

Background Prostaglandin E2 (PGE2) is an important mediator in tumor-promoting
inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the …

To create precise neural circuits in the nervous system, neuritogenesis and synaptogenesis
are the critical cellular processes during neuronal differentiation. We examined the cyclic …