Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a
physiological process that impacts diverse cellular processes. Mitofusins are activated by …

Cell-based therapies represent a very promising strategy to repair and regenerate the
injured heart to prevent progression to heart failure. To date, these therapies have had …