The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Research efforts spanning the past two decades have established a clear link between
nuclear receptor function, regulation of the circadian clock and lipid homeostasis. As such …

Nitric oxide gas acts as a short-range signaling molecule in a vast array of important
physiological processes, many of which include major changes in gene expression. How …

Retinoic acid-related orphan receptors RORα and RORγ play a regulatory role in
lipid/glucose homeostasis and various immune functions, and have been implicated in …

Objective This study investigated the role of microRNAs generated from adipose tissue
macrophages (ATMs) during adipose tissue remodeling induced by pharmacological and …

Obesity is a known risk factor for metabolic diseases and is often associated with chronic
inflammation in adipose tissue. We previously identified the polyethoxylated flavonoid …

Circadian rhythmicity that has been shaped by evolution over millions of years generates an
internal timing controlling the sleep–wake and metabolism cycles. The daily variations …

Retinoid-related orphan receptor (ROR) α4 is the major RORα isoform expressed in adipose
tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice …

The circadian clock plays an essential role in coordinating feeding and metabolic rhythms
with the light/dark cycle. Disruption of clocks is associated with increased adiposity and …

Impairment of skeletal muscle function causes disabilities in elderly people. Therefore, in an
aged society, prevention and treatment of sarcopenia are important for expanding healthy …