Protein misfolding is a general hallmark of protein deposition diseases, such as Alzheimer's
disease or Parkinson's disease, in which different types of aggregated species (oligomers …

The progressive accumulation of insoluble aggregates of the presynaptic protein alpha-
synuclein (α-Syn) is a hallmark of neurodegenerative disorders including Parkinson's …

Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and …

The difficulty of obtaining samples from certain human tissues has led to efforts to find
accessible sources to analyze molecular markers derived from DNA. In this study, we look …

Nanoplastics and polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in soil
environments. In order to objectively evaluate the toxic interaction between polystyrene …

Parkinson's disease (PD) and other synucleinopathies are characterized by the aggregation
and deposition of alpha-synuclein (α-syn) in brain cells, forming insoluble inclusions such as …

In cancer cells, survival genes contribute to uncontrolled growth and the survival of
malignant cells, leading to tumor progression. Neurons are post-mitotic cells, fully …

Parkinson's disease is the second most prevalent neurodegenerative disease and
contributes significantly to morbidity globally. Currently, no disease-modifying therapies exist …

Point-of-care testing (POCT) for low-concentration protein biomarkers remains challenging
due to limitations in biosensor sensitivity and platform integration. This study addresses this …