[HTML][HTML] 2H/4H-Chromenes—A versatile biologically attractive Scaffold

V Raj, J Lee - Frontiers in Chemistry, 2020 - frontiersin.org
2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile
biological profiles, a simple structure, and mild adverse effects. Researchers discovered …

Microwave-assisted synthesis of bioactive heterocycles: An overview

A Adhikari, S Bhakta, T Ghosh - Tetrahedron, 2022 - Elsevier
Microwave-assisted synthesis of numerous bioactive scaffolds has gained much attention of
late in organic chemistry. Most of the heterocyclic rings can be synthesized using the …

A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular …

MT Khayat, HEA Ahmed, AM Omar… - Journal of …, 2023 - Taylor & Francis
All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were
found to have small sizes and high levels of flexibility, and hence showed low selectivity …

Discovery of pyran annulated heterocyclic scaffolds linked to carboxamide fragments: Anticancer evaluation, topoisomerase I/II, tyrosine kinase receptor inhibition and …

AM Fouda, RA El-Eisawy, MAA El-Nassag… - Journal of Molecular …, 2024 - Elsevier
A class of 4H-benzo [h] chromene (4a-h) and 1H-benzo [f] chromene (6a-h) derivatives
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …

First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone …

RM Okasha, M Alsehli, S Ihmaid, SS Althagfan… - Bioorganic …, 2019 - Elsevier
This report presents the development of a novel and primary model of sulfonamide
compounds encompassing a chromene azo motif with the intent of becoming applicable for …

[HTML][HTML] Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported …

AKB Aljohani, WAZ El Zaloa, M Alswah… - International journal of …, 2023 - mdpi.com
Phenylpyrazolo [3, 4-d] pyrimidine is considered a milestone scaffold known to possess
various biological activities such as antiparasitic, antifungal, antimicrobial, and …

Multicomponent synthesis of spiro 1, 3, 4‐thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiation

A Castro, IMG Andrade, MC Coelho… - Journal of …, 2023 - Wiley Online Library
This work describes a simple and efficient alternative method for obtaining 1, 3, 4‐
thiadialzolinic spirocompounds, combining the use of deep eutectic solvents (DES) with …

Characterization of novel heterocyclic compounds based on 4-aryl-4H-chromene scaffold as anticancer agents: Design, synthesis, antiprofilerative activity against …

EKA Abdelall, HAH Elshemy, MB Labib… - Bioorganic …, 2022 - Elsevier
In this study, three novel sets of 4-aryl-4H-chromene derivatives 4a–c, 6a–d and 7a–c were
synthesized and evaluated for anticancer activity. Characterization of new compounds was …

Isocyanide-based multicomponent reactions for the synthesis of benzopyran derivatives with biological scaffolds

MT Nazeri, T Nasiriani, S Torabi… - Organic & Biomolecular …, 2024 - pubs.rsc.org
Benzopyrans (BZPs) are one of the most privileged and influential small O-heterocycles that
form the core of many natural compounds, commercial drugs, biological compositions …

[HTML][HTML] A New Family of Benzo[h]Chromene Based Azo Dye: Synthesis, In-Silico and DFT Studies with In Vitro Antimicrobial and Antiproliferative Assessment

AS Abd-El-Aziz, A Alsaggaf, E Assirey, A Naqvi… - International Journal of …, 2021 - mdpi.com
The high biological activity of the chromene compounds coupled with the intriguing optical
features of azo chromophores prompted our desire to construct novel derivatives of …