Synthesis, assembly, and applications of hybrid nanostructures for biosensing

S Zhang, R Geryak, J Geldmeier, S Kim… - Chemical …, 2017 - ACS Publications
The robust, sensitive, and selective detection of targeted biomolecules in their native
environment by prospective nanostructures holds much promise for real-time, accurate, and …

Cu-catalyzed azide− alkyne cycloaddition

M Meldal, CW Tornøe - Chemical reviews, 2008 - ACS Publications
The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

Applications of orthogonal “click” chemistries in the synthesis of functional soft materials

RK Iha, KL Wooley, AM Nystrom, DJ Burke… - Chemical …, 2009 - ACS Publications
Applications for advanced functional soft materials that possess precisely engineered
properties and functional groups have been expanding significantly with the development of …

Smart chemistry of enzyme immobilization using various support matrices–a review

S Liu, M Bilal, K Rizwan, I Gul, T Rasheed… - International Journal of …, 2021 - Elsevier
The surface chemistry, pendent functional entities, and ease in tunability of various materials
play a central role in properly coordinating with enzymes for immobilization purposes. Due …

The development of microgels/nanogels for drug delivery applications

JK Oh, R Drumright, DJ Siegwart… - Progress in polymer …, 2008 - Elsevier
Microgels/nanogels are crosslinked polymeric particles, which can be considered as
hydrogels if they are composed of water soluble/swellable polymer chains. They possess …

Click chemistry reactions in medicinal chemistry: Applications of the 1, 3‐dipolar cycloaddition between azides and alkynes

GC Tron, T Pirali, RA Billington… - Medicinal research …, 2008 - Wiley Online Library
In recent years, there has been an ever‐increasing need for rapid reactions that meet the
three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions …

1, 3‐Dipolar cycloadditions of azides and alkynes: a universal ligation tool in polymer and materials science

JF Lutz - Angewandte Chemie International Edition, 2007 - Wiley Online Library
In 2001, Sharpless and co‐workers introduced “click” chemistry, a new approach in organic
synthesis that involves a handful of almost perfect chemical reactions. Among these carefully …

Cellular consequences of copper complexes used to catalyze bioorthogonal click reactions

DC Kennedy, CS McKay, MCB Legault… - Journal of the …, 2011 - ACS Publications
Copper toxicity is a critical issue in the development of copper-based catalysts for copper (I)-
catalyzed azide–alkyne cycloaddition (CuAAC) reactions for applications in living systems …

Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications

D Samanta, A Sarkar - Chemical Society Reviews, 2011 - pubs.rsc.org
Attachment of biomolecules on gold, silicon or glass surfaces has direct implications for the
development of novel biosensors in the context of nanoscale detection of pathogens and …

Biopolymer‐based coatings: promising strategies to improve the biocompatibility and functionality of materials used in biomedical engineering

J Song, B Winkeljann, O Lieleg - Advanced Materials Interfaces, 2020 - Wiley Online Library
It was a physicist, Wolfgang Pauli, who recognized a century ago that “God made the bulk;
the surface was invented by the devil.” And indeed, adjusting the surface properties of …