Novel antimicrobial 8-hydroxyquinoline-based agents: Current development, structure–activity relationships, and perspectives

AR Joaquim, MP Gionbelli, G Gosmann… - Journal of Medicinal …, 2021 - ACS Publications
The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

An oxidation responsive nano-radiosensitizer increases radiotherapy efficacy by remolding tumor vasculature

X Wang, X Niu, W Sha, X Feng, L Yu, Z Zhang… - Biomaterials …, 2021 - pubs.rsc.org
As an excellent candidate material for nano-sensitizers, gold nanostructures have shown
great potential in radiotherapy. Nevertheless, severe hypoxia and low accumulation of …

An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review

A Sabt, HO Tawfik, EF Khaleel, RM Badi… - Molecular Diversity, 2024 - Springer
RAS (rat sarcoma) oncoproteins are crucial for the growth of some human cancers, including
lung, colorectal, and pancreatic adenocarcinomas. The RAS family contains three known …

Tuning the hydrolytic behavior of hydroxyquinoline derivatives for anticorrosion applications

N Kongkatigumjorn, P Srikamut, F Seidi… - Chemistry of …, 2022 - ACS Publications
Controlling the rate of hydrolysis of polymer conjugates is of paramount importance for the
timely and precise delivery of drugs, corrosion inhibitors, healing agents, and phytosanitary …

Synthesis of Bioactive Aminomethylated 8-Hydroxyquinolines via the Modified Mannich Reaction

O Csuvik, I Szatmári - International Journal of Molecular Sciences, 2023 - mdpi.com
8-hydroxyquinoline (oxine) is a widely known and frequently used chelating agent, and the
pharmacological effects of the core molecule and its derivatives have been studied since the …

Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors

M Gajic, D Knez, I Sosič, J Mravljak, A Meden… - …, 2022 - Wiley Online Library
A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened
in vitro for inhibition of deoxyribonuclease I (DNase I). Compounds 22, 8 and 7 are among …

Synthesis of Catalyst Using Bio‐benign Precursors and Its Application in One‐Pot Catalytic Synthesis of Imidazo[1,2‐a]pyridines

S Kumar Mishra, A Parikh, K Rangan… - ChemistrySelect, 2023 - Wiley Online Library
Abstract Development of catalysts using natural feedstock is the need of the current era, and
accordingly, we have developed a new ligand N‐(2‐hydroxynapthylidene)‐L‐leucienyl‐4, 6 …

Discovery of quinolinequinones with N-phenylpiperazine by conversion of hydroxyquinoline as a new class of antimicrobial agents targeting resistant pathogenic …

M Yıldız, N Bayrak, H Yıldırım, SM Çakmak… - Bioorganic …, 2022 - Elsevier
The development of new antimicrobial agents is necessary to overcome the emerging
antimicrobial resistance among infectious microbial pathogens. Herein, we successfully …

Polyfunctionalized α-Phenyl-tert-butyl (benzyl) nitrones: Multifunctional Antioxidants for Stroke Treatment

D Diez-Iriepa, D Knez, S Gobec, I Iriepa, C de Los Ríos… - Antioxidants, 2022 - mdpi.com
Nowadays, most stroke patients are treated exclusively with recombinant tissue
plasminogen activator, a drug with serious side effects and limited therapeutic window. For …

Determination of the “Privileged Structure” of 8‐Hydroxyquinoline

D McNaughton, D Wachsmuth, P Kraus… - …, 2021 - Wiley Online Library
An accurate semi‐experimental equilibrium structure of 8‐hydroxyquinoline (8‐HQ) has
been determined combining experiment and theory. The cm‐wave rotational spectrum of 8 …