Mechanism of Action, Resistance, Synergism, and Clinical Implications of Delamanid Against Multidrug-Resistant Mycobacterium tuberculosis
Multidrug-resistant (MDR) isolates of Mycobacterium tuberculosis (MTB) remain a primary
global threat to the end of tuberculosis (TB) era. Delamanid (DLM) is a nitro-dihydro …
global threat to the end of tuberculosis (TB) era. Delamanid (DLM) is a nitro-dihydro …
Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-
resistant (MDR) Mycobacterium tuberculosis (Mtb) strains. In recent years, adding CFZ and …
resistant (MDR) Mycobacterium tuberculosis (Mtb) strains. In recent years, adding CFZ and …
One step forward: successful end-of-treatment outcomes of patients with drug-resistant tuberculosis who received concomitant bedaquiline and delamanid in Mumbai …
M Das, A Dalal, C Laxmeshwar, S Ravi… - Clinical Infectious …, 2021 - academic.oup.com
Background The Médecins Sans Frontières Clinic in Mumbai, India, has been providing
concomitant bedaquiline (BDQ) and delamanid (DLM) in treatment regimen for patients with …
concomitant bedaquiline (BDQ) and delamanid (DLM) in treatment regimen for patients with …
[HTML][HTML] Revised definitions of tuberculosis resistance and treatment outcomes, France, 2006–2019
Y Kherabi, M Fréchet-Jachym, C Rioux… - Emerging infectious …, 2022 - ncbi.nlm.nih.gov
Definitions of resistance in multidrug-resistant tuberculosis (MDR TB) and extensively drug-
resistant tuberculosis (XDR TB) have been updated. Pre–XDR TB, defined as MDR TB with …
resistant tuberculosis (XDR TB) have been updated. Pre–XDR TB, defined as MDR TB with …
[HTML][HTML] Phenotypic and genotypic characterization of levofloxacin-and moxifloxacin-resistant Mycobacterium tuberculosis clinical isolates in southern China
HMA Hameed, Y Tan, MM Islam, L Guo… - Journal of Thoracic …, 2019 - ncbi.nlm.nih.gov
Background Levofloxacin (LVX) and Moxifloxacin (MXF) are the cornerstones for treatment
of multidrug-resistant tuberculosis (MDR-TB). China is one of the highest MDR-and …
of multidrug-resistant tuberculosis (MDR-TB). China is one of the highest MDR-and …
[HTML][HTML] Nationwide treatment outcomes of patients with multidrug/rifampin-resistant tuberculosis in Korea, 2011–2017: a retrospective cohort study (Korean TB-POST)
Background The treatment outcomes of patients with multidrug/rifampin-resistant (MDR/RR)
tuberculosis (TB) are important indicators that reflect the current status of TB management …
tuberculosis (TB) are important indicators that reflect the current status of TB management …
A comparative study of chest computed tomography findings: 1030 cases of drug-sensitive tuberculosis versus 516 cases of drug-resistant tuberculosis
N Cheng, S Wu, X Luo, C Xu, Q Lou, J Zhu… - Infection and Drug …, 2021 - Taylor & Francis
Purpose To investigate the CT features of drug-resistant pulmonary tuberculosis (DR-PTB)
and the diagnostic value of CT in DR-PTB diagnosis to provide imaging evidence for the …
and the diagnostic value of CT in DR-PTB diagnosis to provide imaging evidence for the …
[HTML][HTML] Interim treatment outcomes in multidrug-resistant tuberculosis patients treated sequentially with bedaquiline and delamanid
Objectives The objective of this study was to evaluate the efficacy and safety of the
sequential use of bedaquiline (Bdq) and delamanid (Dlm) in patients with multidrug-resistant …
sequential use of bedaquiline (Bdq) and delamanid (Dlm) in patients with multidrug-resistant …
Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein
AT Adewumi, OS Soremekun, MB Ajadi… - RSC advances, 2020 - pubs.rsc.org
Drug-resistant Tuberculosis (TB) has remained the top global health challenge, with a yearly
estimation of 10 million infections and 1.5 million deaths in humans. Demethylmenaquinone …
estimation of 10 million infections and 1.5 million deaths in humans. Demethylmenaquinone …
Characterization of Fluoroquinolone-Resistant and Multidrug-Resistant Mycobacterium tuberculosis Isolates Using Whole-Genome Sequencing in Tianjin, China
Z Wang, R Sun, C Mu, C Wang, H Zhao… - Infection and Drug …, 2022 - Taylor & Francis
Objective Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a global
concern. This study aimed to determine the molecular characteristics of fluoroquinolone …
concern. This study aimed to determine the molecular characteristics of fluoroquinolone …