[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

X Qu, N Qiu, M Wang, B Zhang, J Du, Z Zhong, W Xu… - Nature, 2022 - nature.com
Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological
processes such as immune responses, organ development, cellular communication …

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet… - Pharmacological …, 2018 - Elsevier
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Endocannabinoids and related N-acylethanolamines: biological activities and metabolism

K Tsuboi, T Uyama, Y Okamoto, N Ueda - Inflammation and Regeneration, 2018 - Springer
The plant Cannabis sativa contains cannabinoids represented by Δ 9-tetrahydrocannabinol,
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …

Mechanisms of adhesion G protein–coupled receptor activation

A Vizurraga, R Adhikari, J Yeung, M Yu… - Journal of Biological …, 2020 - ASBMB
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

Perinatal dietary polyunsaturated fatty acids in brain development, role in neurodevelopmental disorders

M Martinat, M Rossitto, M Di Miceli, S Layé - Nutrients, 2021 - mdpi.com
n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …

Impact of dietary fats on brain functions

R Chianese, R Coccurello, A Viggiano… - Current …, 2018 - ingentaconnect.com
Background: Adequate dietary intake and nutritional status have important effects on brain
functions and on brain health. Energy intake and specific nutrients excess or deficiency from …

Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). I. Drugs …

M Bialer, SI Johannessen, MJ Koepp, E Perucca… - …, 2024 - Wiley Online Library
Abstract For> 30 years, the Eilat Conference on New Antiepileptic Drugs and Devices has
provided a forum for the discussion of advances in the development of new therapies for …