Synthetic molecular cage receptors for carbohydrate recognition

B Wu, R Tang, Y Tan - Nature Reviews Chemistry, 2024 - nature.com
A captivating challenge in chemistry lies in achieving robust and precise binding of
uncharged, hydrophilic carbohydrate entities. Although past decades have provided a …

Molecular engineering of carbohydrate recognition

Z Sun, B Fan, MJ Webber - ChemSystemsChem, 2023 - Wiley Online Library
Carbohydrates play a number of structural, functional, and metabolic roles in underpinning
natural life processes, acting in states of both health and disease. Given this importance …

Catalyst: can systems chemistry unravel the mysteries of the chemical origins of life?

D Kroiss, G Ashkenasy, AB Braunschweig, T Tuttle… - Chem, 2019 - cell.com
Daniela Kroiss obtained her MSc degree in biotechnology at BOKU and is currently a PhD
student in the biochemistry program at CUNY, where she works on a joint project between …

Flexible synthetic carbohydrate receptors as inhibitors of viral attachment

MF Bravo, MA Lema, M Marianski… - Biochemistry, 2020 - ACS Publications
Carbohydrate–receptor interactions are often involved in the docking of viruses to host cells,
and this docking is a necessary step in the virus life cycle that precedes infection and …

Cycloalkyl Groups as Building Blocks of Artificial Carbohydrate Receptors: Studies with Macrocycles Bearing Flexible Side-Arms

B Leibiger, M Stapf, M Mazik - Molecules, 2022 - mdpi.com
The cyclopentyl group was expected to act as a building block for artificial carbohydrate
receptors and to participate in van der Waals contacts with the carbohydrate substrate in a …

Binding modes of methyl α-d-glucopyranoside to an artificial receptor in crystalline complexes

L Köhler, C Hübler, W Seichter, M Mazik - RSC advances, 2021 - pubs.rsc.org
Compared to the numerous X-ray crystal structures of protein-carbohydrate complexes, the
successful elucidation of the crystal structures of complexes between artificial receptors and …

Molecular interrogation to crack the case of O‐GlcNAc

A Estevez, D Zhu, C Blankenship… - Chemistry–A European …, 2020 - Wiley Online Library
The O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) modification, termed O‐GlcNAcylation, is
an essential and dynamic post‐translational modification in cells. O‐GlcNAc transferase …

A synthetic galectin mimic

BJJ Timmer, A Kooijman, X Schaapkens… - Angewandte Chemie …, 2021 - Wiley Online Library
Galectins are a galactoside specific subclass of carbohydrate binding proteins (lectins)
involved in various cellular activities, certain cancers, infections, inflammations, and many …

Towards Biomimetic Recognition of Glycans by Synthetic Receptors

F Milanesi, S Roelens, O Francesconi - ChemPlusChem, 2024 - Wiley Online Library
Carbohydrates are abundant in Nature, where they are mostly assembled within glycans as
free polysaccharides or conjugated to a variety of biological molecules such as proteins and …

Synthesis and Binding of Mannose‐Specific Synthetic Carbohydrate Receptors

MF Bravo, K Palanichamy, MA Shlain… - … A European Journal, 2020 - Wiley Online Library
Synthetic carbohydrate receptors (SCRs) that selectively recognize cell‐surface glycans
could be used for detection, drug delivery, or as therapeutics. Here we report the synthesis …