DNA damage is a key factor affecting gametogenesis and embryo development. The
integrity and stability of DNA are fundamental to a woman's successful conception …

Epigenetic modifications play crucial roles in physiological processes, including cell
differentiation, proliferation, and death. Bromodomain/Brd-containing proteins (BCPs) …

Deoxyribouridine (dU) is an abnormal nucleoside in DNA and plays vital roles in multiple
biological and physiological processes. Here, we conducted a mass spectrometry-based …

Age at exposure is a critical modifier of the risk of radiation-induced cancer. However, the
effects of age on radiation-induced carcinogenesis remain poorly understood. In this study …

As a space project, in “Stem Cells” by the Japan Aerospace Exploration Agency (JAXA),
frozen mouse ES cells were stored on the International Space Station (ISS) in the Minus …

DNA damage tolerance pathways that allow for the completion of replication following fork
arrest are critical in maintaining genome stability during cell division. The main DNA …

Mammalian DNA replication relies on various DNA helicase and nuclease activities to
ensure accurate genetic duplication, but how different helicase and nuclease activities are …

BC, a heterogeneous disease, is thought to be the second leading cause of death in women
globally. In only 70-80% of the BC patients with early-stage, non-metastatic disease is …

SLX4 is an interactor and activator of structure-specific exonuclease that helps resolve
tangled recombination intermediates arising at stalled replication forks. It is one of the many …

It is widely acknowledged that chemoresistance is one of the major consequences that leads
to chemotherapeutic treatment failure and cancer-related death. In recent studies, lots of …