Protein-based adjuvants for vaccines as immunomodulators of the innate and adaptive immune response: Current knowledge, challenges, and future opportunities
DA Díaz-Dinamarca, ML Salazar, BN Castillo… - Pharmaceutics, 2022 - mdpi.com
New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic
than classical vaccines formulated with live-attenuated or inactivated pathogens. This …
than classical vaccines formulated with live-attenuated or inactivated pathogens. This …
Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa
P Dolashka, V Moshtanska, V Borisova, A Dolashki… - Peptides, 2011 - Elsevier
Hemolymph of Rapana venosa snails is a complex mixture of biochemically and
pharmacologically active components such as peptides and proteins. Antimicrobial peptides …
pharmacologically active components such as peptides and proteins. Antimicrobial peptides …
Purification, characterization and molecular cloning of tyrosinase from the cephalopod mollusk, Illex argentinus
T Naraoka, H Uchisawa, H Mori… - European Journal of …, 2003 - Wiley Online Library
Tyrosinase (monophenol, l‐DOPA: oxygen oxidoreductase) was isolated from the ink of the
squid, Illex argentinus. Squid tyrosinase, termed ST94, was found to occur as a covalently …
squid, Illex argentinus. Squid tyrosinase, termed ST94, was found to occur as a covalently …
Glycan structures and antiviral effect of the structural subunit RvH2 of Rapana hemocyanin
Molluscan hemocyanins are very large biological macromolecules and they act as oxygen-
transporting glycoproteins. Most of them are glycoproteins with molecular mass around …
transporting glycoproteins. Most of them are glycoproteins with molecular mass around …
Identification of Glycosylated Sites in Rapana Hemocyanin by Mass Spectrometry and Gene Sequence, and Their Antiviral Effect
P Dolashka-Angelova, B Lieb, L Velkova… - Bioconjugate …, 2009 - ACS Publications
Molluscan hemocyanins (Hcs) have recently received particular interest due to their
significant immunostimulatory properties. This is mainly related to their high carbohydrate …
significant immunostimulatory properties. This is mainly related to their high carbohydrate …
Acid-induced unfolding of didecameric keyhole limpet hemocyanin: detection and characterizations of decameric and tetrameric intermediate states
Keyhole limpet hemocyanin (KLH) is widely used as an immune stimulant and hapten
carrier derived from a marine mollusc Megathura crenulata. To provide details of the stability …
carrier derived from a marine mollusc Megathura crenulata. To provide details of the stability …
Oligomeric stability of Rapana venosa hemocyanin (RvH) and its structural subunits
P Dolashka-Angelova, H Schwarz, A Dolashki… - … et Biophysica Acta (BBA …, 2003 - Elsevier
The two structural subunits RvH1 and RvH2 were separated after overnight dialysis of
Rapana venosa Hc against 130 mM Gly/NaOH buffer, pH 9.6, on an ion exchange column …
Rapana venosa Hc against 130 mM Gly/NaOH buffer, pH 9.6, on an ion exchange column …
Structure of hemocyanin from garden snail Helix lucorum
L Velkova, I Dimitrov, H Schwarz, S Stevanovic… - … and Physiology Part B …, 2010 - Elsevier
Hemocyanins are giant extracellular oxygen carriers in the hemolymph of many molluscs
and arthropods with different quaternary structure. They are represented in the hemolymph …
and arthropods with different quaternary structure. They are represented in the hemolymph …
[PDF][PDF] Changes in the gene expression profile of the bladder cancer cell lines after treatment with Helix lucorum and Rapana venosa hemocyanin
O Antonova, L Yossifova, R Staneva, S Stevanovic… - J. Buon, 2015 - researchgate.net
Purpose: The purpose of this study was to elucidate the mechanism of action of the Helix
lucorum hemocyanin (HlH), b-HlH-h, and RvH2-g hemocyanins as potential agents against …
lucorum hemocyanin (HlH), b-HlH-h, and RvH2-g hemocyanins as potential agents against …
In vitro effect of molluscan hemocyanins on CAL-29 and T-24 bladder cancer cell lines
O Boyanova, P Dolashka, D Toncheva… - Biomedical …, 2013 - spandidos-publications.com
The aim of this study was to investigate the anti-tumor effects of molluscan hemocyanins
(Hcs) isolated from the marine snail Rapana venosa (RvH) and the garden snail Helix …
(Hcs) isolated from the marine snail Rapana venosa (RvH) and the garden snail Helix …