An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

IgM monoclonal gammopathy of undetermined significance is a pre-malignant condition for
Waldenström macroglobulinemia and other B-cell malignancies, defined by asymptomatic …

Neutrophilic dermatoses are a group of clinically heterogeneous diseases characterized by
infiltration of neutrophils in the affected tissue. Skin symptoms comprise a spectrum of …

Autoimmune rheumatic diseases are a cluster of heterogeneous disorders that share some
clinical symptoms such as pain, tissue damage, immune deregulation, and the presence of …

Schnitzler syndrome is a rare disease of adult-onset with main features including chronic
urticarial rash, recurrent fever, arthralgia or arthritis, monoclonal gammopathy of …

Systemic autoinflammatory diseases (SAID) are conditions caused by dysregulation or
disturbance of the innate immune system, with neutrophils and macrophages the main …

Objectives The study is aimed to evaluate the impact of safety events in the Eurofever
registry for Autoinflammatory diseases. Methods This was a retrospective and longitudinal …

The pattern recognition receptors, complement system, inflammasomes, antimicrobial
peptides, and cytokines are innate immunity soluble factors. They sense, either directly or …

The objectives of the study were to present the experience of diagnosis, management, and
therapy with IL-1 inhibitors in patients with Schnitzler's syndrome (SchS) according to a …

Schnitzler syndrome (SchS) is a rare autoimmune and inflammatory disease mediated by
interleukin-1 beta (IL-1β). Recurrent monoclonal gammopathy and chronic urticarial rash are …