Metamizole, also known as dipyrone, was introduced to the market nearly a century ago.
Due to its excellent analgesic, antipyretic, and spasmolytic properties combined with its …

Background Dipyrone (metamizole) is a nonsteroidal anti‐inflammatory drug used in some
countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in other …

Non‐opioid analgesics are widely used for pain relief in palliative medicine. However, there
is a lack of evidence‐based recommendations addressing the efficacy, tolerability, and …

The pyrazolone class comprises a variety of hybrid compounds displaying diverse biological
actions. Although studied for decades, these compounds are still of interest due to their …

Although carbon–carbon, carbon–nitrogen, and carbon–oxygen double bonds or their
combinations have extensively been applied in phosphine-catalyzed asymmetric …

Background Pain is common in older patients and management guidelines rarely consider
the effect of multiple comorbidities and concurrent medications on analgesic selection …

Objectives The aim of this study was to evaluate the effects of dipyrone and tramadol, used
for 5 days, on postoperative pain, hematological and biochemical parameters, and oxidative …

Metamizole (dipyrone) is a widely used non-opioid analgesic in both human and animal
medicine. Metamizole's safety has been the topic of numerous opposing debates, given the …

We have recently shown that dipyrone (metamizole), a non-opioid analgesic, can nullify
aspirin (acetylsalicylic acid; ASA) antiplatelet effects in patients with coronary artery disease …

This study was performed to determine pharmacokinetic profiles of the two active
metabolites of the analgesic drug metamizole (dipyrone, MET), 4‐methylaminoantipyrine …