In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …

Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques.
Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances …

Protein degradation plays important roles in biological processes and is tightly regulated.
Further, targeted proteolysis is an emerging research tool and therapeutic strategy …

Mass spectrometry–based quantitative proteomics is a powerful tool for gaining insights into
function and dynamics of biological systems. However, peptides with different sequences …

To date, the effects of specific modification types and sites on protein lifetime have not been
systematically illustrated. Here, we describe a proteomic method, DeltaSILAC, to …

Recent developments in mass spectrometry-based single-cell proteomics (SCP) have
resulted in dramatically improved sensitivity, yet the relatively low measurement throughput …

Protein degradation occurs through proteasomal, endosomal, and lysosomal pathways.
Technological advancements have allowed for the determination of protein copy numbers …

The coordination of protein synthesis and degradation regulating protein abundance is a
fundamental process in cellular homeostasis. Today, mass spectrometry-based …

Progressive loss of proteostasis is a hallmark of aging that is marked by declines in various
components of proteostasis machinery, including: autophagy, ubiquitin‐mediated …

Regulation of translation is essential during stress. However, the precise sets of proteins
regulated by the key translational stress responses—the integrated stress response (ISR) …