Targeting adipokines in polycystic ovary syndrome and related metabolic disorders: from experimental insights to clinical studies

Y Xu, H Zhu, W Li, D Chen, Y Xu, A Xu, D Ye - Pharmacology & …, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) affects approximately 15% of women of reproductive age
worldwide. It is the most prevalent endocrine disorder with marked risks for female infertility …

Insulin resistance in polycystic ovary syndrome improved by Chinese Medicine Dingkun Pill (定坤丹): a randomized controlled clinical trial

Y Deng, W Xue, Y Wang, X Liu, S Zhu, X Ma… - Chinese Journal of …, 2019 - Springer
Objective To assess the efficacy and safety of the Chinese medicine Dingkun Pill (定坤丹,
DKP) on insulin resistance in women with polycystic ovary syndrome (PCOS). Methods A …

The effect of metformin and myoinositol on metabolic outcomes in women with polycystic ovary syndrome: role of body mass and adiponectin in a randomized …

V Soldat-Stanković, S Popović-Pejičić… - Journal of …, 2022 - Springer
Purpose To compare the effects of insulin sensitizers metformin (MET) and myo-inositol (MI)
on adiponectin levels and metabolic characteristics in women with polycystic ovary …

Food Cravings and Obesity in Women with Polycystic Ovary Syndrome: Pathophysiological and Therapeutic Considerations

K Stefanaki, DS Karagiannakis, M Peppa, A Vryonidou… - Nutrients, 2024 - mdpi.com
Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of
reproductive age, constitutes a metabolic disorder frequently associated with obesity and …

Metabolic alterations associated with polycystic ovary syndrome: A UPLC Q-Exactive based metabolomic study

X Chen, T Lu, X Wang, X Sun, J Zhang, K Zhou, X Ji… - Clinica chimica acta, 2020 - Elsevier
Background The polycystic ovary syndrome (PCOS) is the most common endocrine and
metabolic disorder syndrome of women in reproductive age. Metabolomic studies of the …

Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation

P Kurowska, M Dawid, J Oprocha… - Biology of …, 2023 - academic.oup.com
Spexin (SPX) is a novel neuropeptide and adipokine negatively correlated with obesity and
insulin resistance. A recent study investigated expression and regulatory function of SPX in …

Clinical, hormonal and metabolic parameters in women with PCOS with different combined oral contraceptives (containing chlormadinone acetate versus …

A Podfigurna, B Meczekalski, F Petraglia… - Journal of …, 2020 - Springer
Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 5–
10% of women of reproductive age. It is characterized by chronic anovulation leading to …

[HTML][HTML] Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons

Q Hu, J Jin, H Zhou, D Yu, W Qian, Y Zhong… - Biomedicine & …, 2018 - Elsevier
Polycystic ovarian syndrome (PCOS), the most common endocrine disorder of women in
reproductive age, is typical with hyperandrogenism and disturbance of the hypothalamus …

Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with …

FB Kargasheh, S Ansaripour, N Borumandnia… - PLoS …, 2021 - journals.plos.org
Background Adipokine leptin plays a crucial role in metabolic and reproductive functions.
Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the …

Effects of kisspeptin on pathogenesis and energy metabolism in polycystic ovarian syndrome (PCOS)

T Wang, S Han, W Tian, M Zhao… - Gynecological …, 2019 - Taylor & Francis
Kisspeptin has been shown to participate in the regulation of pituitary hormone secretion
and energy metabolism. In PCOS patients, there are disorders in pituitary hormone secretion …