The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Alongside the exponential flourish of research on age-related trajectories of human brain
development during childhood and adolescence in the past two decades, there has been an …

Objective: A role for aberrant reward processing in the pathogenesis of depression has long
been proposed. However, no review has yet examined its role in depression by integrating …

New evidence of reward processing abnormalities in MDD, bipolar disorder and
schizophrenia has led to a greater understanding of the neural processes associated with …

Early-life trauma is one of the strongest risk factors for later emotional psychopathology.
Although research in adults highlights that childhood trauma predicts deficits in emotion …

Background Emotional neglect is associated with multiple negative outcomes, particularly
increased risk for depression. Motivated by increasing evidence of reward-related ventral …

Objective: A blunted neural response to rewards has recently emerged as a potential
mechanistic biomarker of adolescent depression. The reward positivity, an event-related …

Many neuroimaging studies have investigated reward processing dysfunction in major
depressive disorder. These studies have led to the common idea that major depressive …

Motivational and hedonic impairments are core aspects of a variety of types of
psychopathology. These impairments cut across diagnostic categories and may be critical to …