Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

The inherited platelet disorders are an uncommon cause of symptomatic bleeding. They
may be difficult to diagnose (and are likely to be under‐diagnosed) and pose problems in …

Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …

Inorganic polyphosphate is an abundant component of acidocalcisomes of bacteria and
unicellular eukaryotes. Human platelet dense granules strongly resemble acidocalcisomes …

Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share
various features with lysosomes, but are distinct in function, morphology, and composition …

Platelets release numerous bioactive molecules stored in their granules enabling them to
exert a wide range of effects on the vascular microenvironment. Are these granule cargo …

Gray platelet syndrome (GPS) is an autosomal recessive bleeding disorder that is
characterized by large platelets that lack α-granules. Here we show that mutations in …

Hermansky–Pudlak syndrome (HPS) is a group of 10 autosomal recessive multisystem
disorders, each defined by the deficiency of a specific gene. HPS‐associated genes encode …

Genetic defects of the megakaryocyte lineage give rise to bleeding syndromes of varying
severity. Blood platelets are unable to fulfill their hemostatic function of preventing blood loss …

The gray platelet syndrome (GPS) is a rare inherited disorder of the megakaryocyte (MK)
lineage. Thrombocytopenia and enlarged platelets are associated with a specific absence of …