Raman techniques: fundamentals and frontiers

RR Jones, DC Hooper, L Zhang, D Wolverson… - Nanoscale research …, 2019 - Springer
Driven by applications in chemical sensing, biological imaging and material
characterisation, Raman spectroscopies are attracting growing interest from a variety of …

Second harmonic generation microscopy: a powerful tool for bio-imaging

A Aghigh, S Bancelin, M Rivard, M Pinsard… - Biophysical …, 2023 - Springer
Second harmonic generation (SHG) microscopy is an important optical imaging technique in
a variety of applications. This article describes the history and physical principles of SHG …

Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure

X Chen, O Nadiarynkh, S Plotnikov, PJ Campagnola - Nature protocols, 2012 - nature.com
Second-harmonic generation (SHG) microscopy has emerged as a powerful modality for
imaging fibrillar collagen in a diverse range of tissues. Because of its underlying physical …

Collagen reorganization at the tumor-stromal interface facilitates local invasion

PP Provenzano, KW Eliceiri, JM Campbell, DR Inman… - BMC medicine, 2006 - Springer
Background Stromal-epithelial interactions are of particular significance in breast tissue as
misregulation of these interactions can promote tumorigenesis and invasion. Moreover …

Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer

JS Bredfeldt, Y Liu, CA Pehlke… - … of biomedical optics, 2014 - spiedigitallibrary.org
Second-harmonic generation (SHG) imaging can help reveal interactions between collagen
fibers and cancer cells. Quantitative analysis of SHG images of collagen fibers is challenged …

Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms

PJ Campagnola, LM Loew - Nature biotechnology, 2003 - nature.com
Although the nonlinear optical effect known as second-harmonic generation (SHG) has
been recognized since the earliest days of laser physics and was demonstrated through a …

Two-photon excitation fluorescence microscopy

PTC So, CY Dong, BR Masters… - Annual review of …, 2000 - annualreviews.org
▪ Abstract Two-photon fluorescence microscopy is one of the most important recent
inventions in biological imaging. This technology enables noninvasive study of biological …

Mueller matrix polarimetry—an emerging new tool for characterizing the microstructural feature of complex biological specimen

H He, R Liao, N Zeng, P Li, Z Chen… - Journal of Lightwave …, 2018 - ieeexplore.ieee.org
Recently, with the emergence of new light sources, polarization devices, and detectors,
together with a prominent increase in data processing capability, polarization techniques …

Second harmonic generation imaging microscopy: applications to diseases diagnostics

P Campagnola - Analytical chemistry, 2011 - ACS Publications
Second Harmonic Generation Imaging Microscopy: Applications to Diseases Diagnostics |
Analytical Chemistry ACS ACS Publications C&EN CAS Find my institution Log In Analytical …

Interpreting second-harmonic generation images of collagen I fibrils

RM Williams, WR Zipfel, WW Webb - Biophysical journal, 2005 - cell.com
Fibrillar collagen, being highly noncentrosymmetric, possesses a tremendous nonlinear
susceptibility. As a result, second-harmonic generation (SHG) microscopy of collagen …