Treatment of stress urinary incontinence with muscle stem cells and stem cell components: chances, challenges and future prospects

FA Schmid, JK Williams, TM Kessler, A Stenzl… - International journal of …, 2021 - mdpi.com
Urinary incontinence (UI) is a major problem in health care and more than 400 million
people worldwide suffer from involuntary loss of urine. With an increase in the aging …

Mesenchymal stem cell-based therapy for female stress urinary incontinence

X Liu, T Li, J Zhang, X Lin, W Wang, X Fan… - Frontiers in Cell and …, 2023 - frontiersin.org
Stress urinary incontinence (SUI) adversely affects the quality of life of patients, while the
currently available surgical and non-surgical therapies are not effective in all patients …

Interaction between macrophages and human Mesenchymal stromal cells derived from bone marrow and Wharton's Jelly—a comparative study

M Dymowska, A Aksamit, K Zielniok, M Kniotek… - Pharmaceutics, 2021 - mdpi.com
Despite intensive clinical research on the use of mesenchymal stromal cells (MSCs), further
basic research in this field is still required. Herein, we compared human bone marrow MSCs …

Intraurethral co-transplantation of bone marrow mesenchymal stem cells and muscle-derived cells improves the urethral closure

A Burdzinska, B Dybowski… - Stem Cell Research & …, 2018 - Springer
Background Cell therapy constitutes an attractive alternative to treat stress urinary
incontinence. Although promising results have been demonstrated in this field, the …

A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex

L Jäger, W Linzenbold, A Fech… - Neurourology and …, 2020 - Wiley Online Library
Aims In a recent preclinical study, we noticed that injection of cells in the urethral sphincter
by needle through a cystoscope under visual control frequently yielded in misplacement or …

Replacing needle injection by a novel waterjet technology grants improved muscle cell delivery in target tissues

R Geng, J Knoll, N Harland, B Amend… - Cell …, 2022 - journals.sagepub.com
Current regimen to treat patients suffering from stress urinary incontinence often seems not
to yield satisfactory improvement or may come with severe side effects. To overcome these …

Rapid and precise delivery of cells in the urethral sphincter complex by a novel needle‐free waterjet technology

W Linzenbold, L Jäger, H Stoll, T Abruzzese… - Bju …, 2021 - Wiley Online Library
Objectives To investigate the therapy of stress urinary incontinence in a preclinical setting
cells were injected into the urethrae of minipigs; however, cells injected by William's needle …

MSC-based therapy in female pelvic floor disorders

Y Sima, Y Chen - Cell & Bioscience, 2020 - Springer
Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells or
mesenchymal stromal cells, are present in multiple tissues and capable of differentiating into …

Current status of stem cell treatments and innovative approaches for stress urinary incontinence

MM Seval, K Koyuncu - Frontiers in Medicine, 2022 - frontiersin.org
Stem cells are capable of self-renewal, differentiation, and the promotion of the release of
chemokines and progenitor cells essential for tissue regeneration. Stem cells have the …

[HTML][HTML] A New Era for a New Concept: Endometrial/Menstrual Mesenchymal Stem Cells and Their Secretome for Prevention and Treatment of pelvic Floor Disorders

MC Russu - 2024 - intechopen.com
High-rate complications and recurrences in reconstructive surgery using in situ synthetic/
polypropylene meshes have driven to a new era of mesenchymal stem cells (MSCs) and/or …