This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

This e-book will review special features of the cerebral circulation and how they contribute to
the physiology of the brain. It describes structural and functional properties of the cerebral …

The vascular myogenic response refers to the acute reaction of a blood vessel to a change
in transmural pressure. This response is critically important for the development of resting …

Atherosclerotic vascular disease is the most common cause of morbidity and mortality in
developed countries, and the world-wide importance of acute vascular syndromes is …

The myogenic response of small arteries and arterioles has been shown to contribute
significantly to autoregulation in different vascular beds. It is characterized by a constriction …

The smooth muscle of arterioles responds to an increase in intraluminal pressure with
vasoconstriction and with vasodilation when pressure is decreased. Such myogenic …

Potassium (K+) ion channel activity is an important determinant of vascular tone by
regulating cell membrane potential (MP). Activation of K+ channels leads to membrane …

Mechanosensitivity is a universal property of cells and provides an obvious survival
advantage for free living organisms who must back away from barriers and evade predators …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …